- Original Article
- The corrected QT (QTc) prolongation in hyperthyroidism and the association of thyroid hormone with the QTc interval
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Ye Seung Lee, Joong Wan Choi, Eun Ju Bae, Won Il Park, Hong Jin Lee, Phil Soo Oh
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Clin Exp Pediatr. 2015;58(7):263-266. Published online July 22, 2015
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Purpose Ventricular repolarization is assessed using the QT interval corrected by the heart rate (QTc) via an electrocardiogram (ECG). Prolonged QTc is associated with an increased risk of arrhythmias and cardiac mortality. As there have been few reports regarding the effects of hyperthyroidism on ventricular repolarization, we studied the association between serum free thyroxine (free T4 [fT4]) and thyroid stimulating hormone... |
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- Case Report
- Identification of a novel mutation in a patient with pseudohypoparathyroidism type Ia
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Ye Seung Lee, Hui Kwon Kim, Hye Rim Kim, Jong Yoon Lee, Joong Wan Choi, Eun Ju Bae, Phil Soo Oh, Won Il Park, Chang Seok Ki, Hong Jin Lee
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Clin Exp Pediatr. 2014;57(5):240-244. Published online May 31, 2014
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Pseudohypoparathyroidism type Ia (PHP Ia) is a disorder characterized by multiform hormonal resistance including parathyroid hormone (PTH) resistance and Albright hereditary osteodystrophy (AHO). It is caused by heterozygous inactivating mutations within the Gs alpha-encoding GNAS exons. A 9-year-old boy presented with clinical and laboratory abnormalities including hypocalcemia, hyperphosphatemia, PTH resistance, multihormone resistance and AHO (round face, short stature, obesity, brachydactyly... |
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- Original Article
- Inherited metabolic diseases in the urine organic acid analysis of complex febrile seizure patients
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Hee Jeong Cheong, Hye Rim Kim, Seong Soo Lee, Eun Joo Bae, Won Il Park, Hong Jin Lee, Hui Chul Choi
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Clin Exp Pediatr. 2009;52(2):199-204. Published online February 15, 2009
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Purpose : Seizure associated with fever may indicate the presence of underlying inherited metabolic diseases. The present study was performed to investigate the presence of underlying metabolic diseases in patients with complex febrile seizures, using analyses of urine organic acids.
Method : We retrospectively analyzed and compared the results of urine organic acid analysis with routine laboratory findings in 278... |
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- Organic acidemias in Korea - Eight years experience of organic acid analysis -
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Jun Suck Bang, Si Hong Lim, Kyung Hwa Lee, Eun Joo Bae, Won Il Park, Hong Jin Lee
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Clin Exp Pediatr. 2006;49(3):258-267. Published online March 15, 2006
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Purpose : We have done this retrospective study to know the relative incidence and clinical manifestations of organic acidopathies in Korea during 8 years(from Jul. 1997 to May 2005). This results of organic acid analysis of 1,787 patients were compared with the results of organic acid analysis that were published three years ago.
Methods : The results of quantitative organic acid... |
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- Reye syndrome after acute enteritis during the neonatal period
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Jun Suck Bang, Sang Jung Nam, Kyung Hwa Lee, Eun Joo Bae, Won Il Park, Hyun Sook Lee, Bae Young Son, Hwan Suck Choi, Hong Jin Lee
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Clin Exp Pediatr. 2006;49(3):273-277. Published online March 15, 2006
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Purpose : The reinfection rate of H. pylori reported before 13C-urea breath test(13C-UBT) era was higher than that of the post 13C-UBT era. Children are usually reluctant to receive invasive endoscopic evaluation for the reinfection of H. pylori, particularly when they are asymptomatic. The aim of the study is to discover the reinfection rate by different diagnostic tests, and to... |
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- Urine Organic Acid Analysis of Patients with Febrile Seizures
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Dong Soo Shin, Gun Jun Lee, Kyeung Ja Lee, Won Il Park, Eun Joo Bae, Hong Gin Lee
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Clin Exp Pediatr. 2004;47(11):1205-1209. Published online November 15, 2004
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Purpose : Febrile seizure, the most common seizure disorder in children between 6 months and 5 years of age, is mostly caused by viral infections, except severe CNS infection. It can also be caused by disorders in organic acid metabolism, especially accompanied by fever. Therefore we decided to investigate the relationship between children with febrile seizures and disorders in organic... |
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- Quantification of Organic Acids in Amniotic Fluid for Prenatal Diagnosis of Organic Acidemia
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Chang Bum Koh, Dong Soo Shin, Eun Joo Bae, Won Il Park, Kyeung Ja Lee, Hong Jin Lee, Young Jo, Seung Won Lee, Ui Sun Noh
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Clin Exp Pediatr. 2004;47(10):1047-1052. Published online October 15, 2004
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Purpose : Since 1997, the quantification of organic acids in urine has become possible in Korea. This helped to diagnose a great variety of inborn errors of metabolism. However, we still don't know the normal value of organic acids in amniotic fluid, therefore it is impossible for doctors to make a correct diagnosis of inborn errors of metabolism in prenatal... |
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- Case Report
- A Case of Dominantly Inherited β Thalassemia
Due to Hb Dieppe
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You Kyoung Choi, Hong Jin Lee, Won Il Park, Kyung Ja Lee, Sung Ha Kang, Ji Yeon Kim, Sung Sup Park
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Clin Exp Pediatr. 2002;45(5):659-663. Published online May 15, 2002
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β thalassemias are usually transmitted as autosomal recessive traits. However, some dominant forms of β thalassemia have been identified in individuals who have inherited a single copy of an abnormal β globin gene. Thalassemia intermedia with mild anemia, jaundice, and splenomegaly has been observed in these patients. Electrophoresis has shown elevated Hemoglobin(Hb) A2 and Hb F levels. In particular, there... |
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- Original Article
- Organic Acidemias in Korea
- Three Years Experience of Organic Acid Analysis -
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You Kyoung Choi, Eung Seok Kim, Eun Joo Bae, Won Il Park, Kyung Ja Lee, Hong Jin Lee
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Clin Exp Pediatr. 2002;45(11):1346-1358. Published online November 15, 2002
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Purpose : We have done this retrospective study to know the relative incidences and clinical manifestations of organic acidopathies in Korea.
Methods : The results of quantitative organic acid analysis of 1,125 samples of 712 patients, referred from Jul. 1997 to Jun. 2000, were analyzed retrospectively according to four age groups (-2 mon, 3 mon-2 year, 3 years-12 years, over... |
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- Quantification of Age-related Reference Values for Urinary Organic Acids in the Healthy Korean Population
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Yong Jae Choi, In Cheol Kim, You Kyoung Choi, Hong Jin Lee, Bong Sung Kim, Won Il Park, Kyoung Ja Lee, T. Giudic, M. Blaskovics
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Clin Exp Pediatr. 2001;44(12):1413-1423. Published online December 15, 2001
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Purpose : For the accurate diagnosis of organic acidopathies, quantification of urinary organic acid
should be done and we should know the normal ranges of each organic acid excreted in the
urine. The amount of organic acids excreted in the urine shows wide variability according to ethnic
group, diet and age. We have quantified 82 organic acids to make a Korean reference value.
Methods... |
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- Case Report
- A Case of Maple Syrup Urine Disease Controlled by Peritoneal Dialysis and Diet
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Ju Wan Kim, June Huh, Won Il Park, Kyung Ja Lee, Hong Jin Lee
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Clin Exp Pediatr. 2001;44(1):94-98. Published online January 15, 2001
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Maple syrup urine disease is an autosomal recessive disease caused by a deficiency of the branched-chain α-ketoacid dehydrogenase complex.
The disease is often suspected because of the peculiar odor of maple syrup in urine. Maple syrup urine disease is usually confirmed by amino acid analysis and urine organic acid analysis showing marked elevations of leucine, isoleucine, valine, and respective ketoacids in... |
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- Original Article
- Age Related Ca, Phosphorus, Uric acid concentration in Serum & Urine and Ca/Cr ratio, Cua/Ccr & TRP
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Jah In Kim, Sang Joo Han, Hong Jin Lee, Won Il Park, Kyung Ja Lee
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Clin Exp Pediatr. 1996;39(10):1405-1413. Published online October 15, 1996
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Purpose : There are many methods for the evaluation of the renal function. The proximal
tubule of the nephrons have a role of reabsorption of the materials such as water, electrolytes,
glucose, amino acids, and small molecular weight protein through the glomerular filtration.
Therefore if abnormality is in the proximal tubule, these materials can be changed both in serum
& urine. It is very... |
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- A Clinical Study of Benign Epilepsy of Childhood with Centrotemporal Spikes
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Byung Il Lee, Sang Ju Han, Hong Jin Lee, Won Il Park, Kyung Ja Lee
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Clin Exp Pediatr. 1994;37(9):1251-1256. Published online September 15, 1994
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Benign epilepsy of childhood with centrotemporal spikes(BECCT) is an electroclinical syndrome characterized by noctural seizure that remit spontaneouly before adulthood, and belong to idiopathic age and location related epilepsies.
We reviewed the medical records to analyse the seizure pattern, and also inspect the EEG recording to identify topography of the epileptiform discharge of 24 patient who met the following criteria: 1)presence... |
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- Clinical Observation of urinary Tract Anomalies
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In Hee Jung, Hong Jin Lee, Sang Joo Han, Won Il Park, Kyung Ja Lee
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Clin Exp Pediatr. 1994;37(8):1092-1096. Published online August 15, 1994
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Urinary tract anomaly is the most common anomaly in childhood. We reviewed medical records of 45 patients who were confirmed urinary tract anomalies on radiologic studies as Chuncheon Sacred Hospital, from Dec. 1984 to Sep. 1992. We analyzed incidence and clinical characteristics of urinary tract anomalies.
The results obtained were as follows:
1) The age distrtibution were: 17 cases (37.8%) under... |
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- Effect of Different Levels of the Dietary Protein on Long Term Prognosis of Experimental Renal Damage
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Choon Haeng Lee, Sang Joo Han, Hong Jin Lee, Won Il Park, Kyung Ja Lee, Young Eui Park, Min Chul Lee, Tae Heon Yoon
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Clin Exp Pediatr. 1993;36(6):820-829. Published online June 15, 1993
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We examined the effect of various levels of dietary protein on long term prognosis of Adriamycinephropathy of S-D rat, fed with high protein(30%), intermediately low(10%), and strictly low(5%) protein diet for 15 weeks
1) In rats fed with strictly low protein diets(5%), proteinuria and serum creatinine decreased and creatinine clearance and histological changes were relatively well preserved. But hypoproteinmia and weight... |
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- Case Report
- A Case of Stein-Leventhal Syndrome with Severe Obesity
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Kyeong Sang Kim, In Hee Jung, Hong Jin Lee, Won Il Park, Kyung Ja Lee
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Clin Exp Pediatr. 1992;35(8):1164-1168. Published online August 15, 1992
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We experienced a extremely rare case of Stein-Leventhal Syndrome in 7 year-old female patient. Her chief complaints was severe obesity. We performed specific radiologic and hormonal studies. Diagnosis was suspected by pelvic sono and CT. We performed vertical gastroplasty with Taplon bandage for morbid obesity. A brief review of related literature was made. |
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- Original Article
- A Case of Lamellar Ichthyosis.
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Yeon Seung Lim, Sang Joo Han, Won Il Park, Kyung Ja Lee
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Clin Exp Pediatr. 1990;33(7):1018-1023. Published online July 31, 1990
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We observed a case of lamellar ichthyosis who was 4 day-old boy with the chief complaints of poor
feeding, exessive lamellated scale covering entire body. Diagnosis of lamellar ichthyosis was estab-
lished by clinical features and histopathological study.
A brief review of literature was made. |
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- A Case of Congenital Cysitic Adenomatoid Malformation of Lung.
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Youe Kawn Kim, Deuk Hwan Jun, Bae Young Kim, Won Il Park, Kyung Ja Lee
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Clin Exp Pediatr. 1990;33(2):225-228. Published online February 28, 1990
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Congenital cystic adenomatoid malformation is a rare variant of pulmonary cystic disease char-
acterized by a mass of cysts lined by proliferating bronchial or cuboidal epithelium. The onset of
symptoms, which are cyanosis, and tachypnea, usually occurs during the first week of life.
We have experienced a case of congenital cystic adenomatoid malformation in a 9 month-old
female. The diagnosis was mady by chest... |
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- A Case of Rickettsia Typhi.
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Deuk Hwan Jun, Sang Joo Han, Bae Young Kim, Won Il Park, Kyung Ja Lee
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Clin Exp Pediatr. 1989;32(12):1736-1739. Published online December 31, 1989
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We experienced one case of rickettsia typhi.
This 6 years old male was admitted to Sacred Heart Hospital because of fever, Headache and
myalgia for 10 days.
Physical examination showed him to have injection of throat, dry lips with no skin rash.
In the laboratory findings, the CSF showed cell count 22/mm3and suger and protein were with in
normal limit.
In peripheral blood smear, moderate left... |
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- Clinical study of intussusception in infants and childhood.
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Sang Joo Han, Yeon Sung Lim, Bae Young Kim, Won Il Park, Kung Ja Lee
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Clin Exp Pediatr. 1989;32(11):1489-1495. Published online November 30, 1989
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Intussusception is an invagination of a segment of the gastrointestinal tract into an adjacent
segment. It is the most common cause of acquired intestinal obstruction during infancy and early
childhood.
We compared the results of treatment with Barium Enema in 33 cases with that of Controlled Air
Insufflation in 31 cases from January, 1985 to December, 1987.
The results were as follows:
1) In age incidence, 86%... |
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